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Genetic element
(GENE)
last updated: 06 May 2020
Neuraminidase
EN
NA
EN
Protein coding sequence
No
-
BCH-ORGA-SCBD-45782-7 Organism Influenza A virus (Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu)Viruses
EN
EN
Neuraminidase (NA) catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. The enzyme facilitates viral release during viral budding by cleaving terminal sialic acids on glycosylated hemagglutinin and prevent self-aggregation. NA may additionally facilitate the cell-to-cell spread of the virus by removing sialic acid residues from cell surfaces. Cleavage of sialic acid residues may also facilitate viral movement through mucus. NA plays a role in determining host range, replication and virulence.
EN
Neuraminidase is denoted by an N number in the Influenza strain. There are 11 subtypes of NA in influenza A viruses.
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- UniProtKB - Neuraminidase [ English ]
- Influenza virus neuraminidase structure and functions.pdf [ English ]
- Influenza neuraminidase.pdf [ English ]
- Role of Neuraminidase in Influenza A(H7N9) Virus Receptor Binding.pdf [ English ]
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